滋賀医科大学 分子診断病理学部門

①-1 早期胃癌と進行胃癌との関係、胃癌の進展機構:ゲノムDNA解析からみた未分化型の早期胃癌と進行胃癌との系譜上の関係と進展機構

Sonoda A, Mukaisho K, Nakayama T, Diem VT, Hattori T, Andoh A, Fujiyama Y, Sugihara H.
Genetic lineages of undifferentiated-type gastric carcinomas analysed by unsupervised clustering of genomic DNA microarray data.
BMC Med Genomics 2013, 6:25 [doi:10.1186/1755-8794-6-25]  <PDF><PubMed Abstract>


杉原 洋行
がんの進展とDNA ploidyの変化
Cytometry Research 20 (1) : 49-56, 2010  <PDF>


杉原 洋行
腺管腺癌に由来する未分化型胃癌の系譜解析
Cytometry Research 17 (2) : 19-24, 2007  <PDF>


Yoshimura A, Sugihara H, Ling ZQ, Peng DF, Mukaisho K, Fujiyama Y, Hattori T.
How wild-type TP53 is inactivated in undifferentiated-type gastric carcinomas: analyses of intratumoral heterogeneity in deletion and mutation of TP53.
Pathobiology 73 (1) : 40-49, 2006  <PubMed Abstract>


杉原 洋行
未分化型胃癌の系譜解析
Cytometry Research 15 (1) : 47-53, 2005  <PDF>


Peng DF, Sugihara H, Mukaisho K, Ling ZQ, Hattori T.
Genetic lineage of poorly differentiated gastric carcinoma with a tubular component analysed by comparative genomic hybridization.
J Pathol 203 (4) : 884-895, 2004  <PubMed Abstract>


Peng DF, Sugihara H, Mukaisho K, Tsubosa Y, Hattori T.
Alterations of chromosomal copy number during progression of diffuse-type gastric carcinomas: metaphase- and array-based comparative genomic hybridization analyses of multiple samples from individual tumours.
J Pathol 201 (3) : 439-450, 2003  <PubMed Abstract>


Moritani S, Sugihara H, Kushima R, Hattori T.
Different roles of p53 between Epstein-Barr virus-positive and -negative gastric carcinomas of matched histology.
Virchows Arch 440 (4) : 367-375, 2002  <PubMed Abstract>


Bamba M, Sugihara H, Okada K, Bamba T, Hattori T.
Clonal analysis of superficial depressed-type gastric carcinoma in humans.
Cancer 83 (5) : 867-875, 1998  <PubMed Abstract>


Sugihara H, Hattori T, Fukuda M, Katsura K, Fujita S.
Progression of signet ring cell carcinomas in the human stomach.
Cancer 71 (6) : 1938-1947, 1993  <PubMed Abstract>


Sugihara H, Hattori T, Fujita S, Hirose K, Fukuda M.
Regional ploidy variations in signet ring cell carcinomas of the stomach.
Cancer 65 (1) : 122-129, 1990  <PubMed Abstract>