滋賀医科大学 分子診断病理学部門

②-2 胆汁による発癌と癌進展:バレット食道及び食道腺癌、食道扁平上皮癌の研究

Mukaisho K, Nakayama T, Hagiwara T, Hattori T, Sugihara H.
Two distinct etiologies of gastric cardia adenocarcinoma: interactions among pH, Helicobacter pylori, and bile acids.
Front Microbiol. 2015 May 11;6:412. doi: 10.3389/fmicb.2015.00412. eCollection 2015.  <PubMed Abstract>


Mukaisho K, Hagiwara T, Nakayama T, Hattori T, Sugihara H.
Potential mechanism of corpus-predominant gastritis after PPI therapy in Helicobacter pylori-positive patients with GERD.
World J Gastroenterol. 2014 Sep 14;20(34):11962-5. doi: 10.3748/wjg.v20.i34.11962. Review.  <PubMed Abstract>


Miyashita T, Tajima H, Munemoto M, Shah FA, Harmon JW, Watanabe T, Shoji M, Okamoto K, Nakanuma S, Sakai S, Kinoshita J, Makino I, Nakamura K, Hayashi H, Oyama K, Inokuchi M, Nakagawara H, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Mukaisho K, Fujimura T, Ohta T.
Impact of histone deacetylase 1 and metastasis-associated gene 1 expression in esophageal carcinogenesis.
Oncol Lett. 2014 Aug;8(2):758-764. Epub 2014 May 26.  <PubMed Abstract>


Macke RA, Nason KS, Mukaisho K, et al.
Barrett’s esophagus and animal models.
Annals of the New York Academy of Sciences, 1232 : 392-400, 2011  <PubMed Abstract>


向所 賢一, 九嶋 亮治, 竹村 しづき, 荒木 克夫, Michael Vieth, 杉原 洋行, 服部 隆則
Barrett食道の組織発生-人体病理と実験病理から
胃と腸, 46: 1861-1874, 2011


向所 賢一, 服部 隆則, 荒木 克夫, 杉原 洋行
Barrett食道腺癌の成因と発癌のメカニズムはどこまで解明されているか
消化器の臨床, 14: 449-454, 2011


Ling ZQ, Mukaisho K, Yamamoto H, Chen KH, Asano S, Araki Y, Sugihara H, Mao WM, Hattori T.
Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma.
Cancer Sci 101 (3) : 624-30, 2010  <PubMed Abstract>


向所 賢一, 杉原 洋行, 服部 隆則
病理医から見たBarrett粘膜とBarrett腺癌―米国人に多いLSBEと我が国に多いSSBEの組織型の違いについて
G.I. Research 18 (1) : 13-18, 2010  <PDF>


Chen KH, Mukaisho K, Sugihara H, Araki Y, Yamamoto G, Hattori T.
High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett’s esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model.
Cancer Sci 98 (11) : 1683-8, 2007  <PubMed Abstract>


Chen KH, Mukaisho K, Ling ZQ, Shimomura A, Sugihara H, Hattori T.
Association between duodenal contents reflux and squamous cell carcinoma–establishment of an esophageal cancer cell line derived from the metastatic tumor in a rat reflux model.
Anticancer Res 27 (1A) : 175-8, 2007  <PubMed Abstract>


Tatsuta T, Mukaisho K, Sugihara H, Miwa K, Tani T, Hattori T.
Expression of Cdx2 in early GRCL of Barrett’s esophagus induced in rats by duodenal reflux.
Dig Dis Sci 50 (3) : 425-431, 2005  <PubMed Abstract>


Kumagai H, Mukaisho K, Sugihara H, Miwa K, Yamamoto G, Hattori T.
Thioproline inhibits development of esophageal adenocarcinoma induced by gastroduodenal reflux in rats.
Carcinogenesis 25 (5) : 723-727, 2004  <PubMed Abstract>


Kumagai H, Mukaisho K, Sugihara H, Miyashita T, Miwa K, Hattori T.
Cell kinetic study on histogenesis of Barrett’s esophagus using rat reflux model.
Scand J Gastroenterol 38 (7) : 687-692, 2003  <PubMed Abstract>