共同研究

① エズリンノックダウンマウスを用いた胃酸分泌制御機構の解明(立命館大学薬学部 浅野真司教授のグループとの共同研究)

② イオンチャンネルの制御因子と癌の関係(山本裕人博士との共同研究)

③ デキストラン硫酸ナトリウムによるラット実験大腸炎(荒木克夫客員准教授との共同研究)

④ 大腸癌の予後規定因子(本学外科学講座との共同研究)

⑤ 大腸癌の進展因子(京都府立医科大学 消化器内科との共同研究)

⑥ 精巣腫瘍の分子遺伝学(本学泌尿器科学講座との共同研究)

② イオンチャンネルの制御因子と癌との関係

(山本裕人博士との共同研究)

  • Yamamoto H, Mukaisho K, Sugihara H, Hattori T, Asano S.
  • Down-regulation of FXYD3 is induced by transforming growth factor-β signaling via ZEB1/δEF1 in human mammary epithelial cells.
  • Biol Pharm Bull 34 (3) : 324-329, 2011  <PubMed Abstract>
  • Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.
  • FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.
  • Biol Pharm Bull 32 (7) : 1148-1154, 2009  <PubMed Abstract>

③ デキストラン硫酸ナトリウムによるラット実験大腸炎

(荒木克夫客員准教授との共同研究)

  • Araki Y, Bamba T, Mukaisho K, Kanauchi O, Ban H, Bamba S, Andoh A, Fujiyama Y, Hattori T, Sugihara H.
  • Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis.
  • Oncology Reports, 28 (5) : 1597-1605, 2012 <PubMed Abstract>
  • Araki Y, Mukaisho K, Sugihara H, Fujiyama Y, Hattori T.
  • Proteus mirabilis sp. intestinal microflora grow in a dextran sulfate sodium-rich environment.
  • Int J Mol Med 25 (2) : 203-208, 2010  <PubMed Abstract>
  • Araki Y, Mukaisyo K, Sugihara H, Fujiyama Y, Hattori T.
  • Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice.
  • Oncol Rep 24 (4) : 869-874, 2010  <PubMed Abstract>
  • Araki Y, Mukaisho K, Sugihara H, Fujiyama Y, Hattori T.
  • Detection of N-nitroso-bile acids at 285 nm in reverse-phase HPLC.
  • J Sep Sci 31 (15) : 2827-2830, 2008  <PubMed Abstract>
  • Araki Y, Mukaisho K, Sugiahra H, Hattori T.
  • Decomposition of dextran sulfate sodium under alkaline, acidic, high temperature and high pressure conditions.
  • Oncol Rep 20 (1) : 147-149, 2008  <PubMed Abstract>
  • Araki Y, Sugihara H, Hattori T.
  • Chemical depolymerization of dextran sulfate sodium – the application of size-exclusion or ion-pair liquid chromatography.
  • Biomed Chromatogr 21 (4) : 335-337, 2007  <PubMed Abstract>
  • Araki Y, Kanauchi O, Sugihara H, Fujiyama Y, Hattori T.
  • Germinated barley foodstuff suppresses dextran sulfate experimental colitis in rats: the role of mast cells.
  • Int J Mol Med 19 (2) : 257-262, 2007  <PubMed Abstract>
  • Araki Y, Sugihara H, Hattori T.
  • In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis.
  • Oncol Rep 16 (6) : 1357-1362, 2006  <PubMed Abstract>
  • Araki Y, Sugihara H, Hattori T.
  • The free radical scavengers edaravone and tempol suppress experimental dextran sulfate sodium-induced colitis in mice.
  • Int J Mol Med 17 (2) : 331-4, 2006  <PubMed Abstract>

④ 大腸癌の予後規定因子

(本学外科学講座との共同研究)

  • Khanh DT, Mekata E, Mukaisho KI, Sugihara H, Shimizu T, Shiomi H, Murata S, Naka S, Yamamoto H, Endo Y, Tani T.
  • Muc1 Overexpression And Its Association With Cd10+ Myeloid Cells, Tgf-Β1 Expression, And Tumor Budding Grade In Colorectal Cancer.
  • Cancer Sci, 104 (7) : 958-64, 2013 <PubMed Abstract>
  • Khanh DT, Mekata E, Mukaisho KI, Shimizu T, Tatsuta T, Sugihara H, Endo Y, Kurumi Y, Tani T.
  • Myeloid cells positive for CD10 at invasion front can predict poor outcome in stage II colorectal cancer
  • Int J Clin Oncol, 17 (3) : 240-249, 2012 <PubMed Abstract>
  • Khanh do T, Mekata E, Mukaisho K, Sugihara H, Shimizu T, Shiomi H, Murata S, Naka S, Yamamoto H, Endo Y, Tani T.
  • Prognostic role of CD10(+) myeloid cells in association with tumor budding at the invasion front of colorectal cancer.
  • Cancer Sci, 102 (9) : 1724-1733, 2011  <PubMed Abstract>

⑤ 大腸癌の進展因子

(京都府立医科大学 消化器内科との共同研究)

  • Tatsumi N, Mukaisho K, Mitsufuji S, Tatsumi Y, Sugihara H, Okanoue T, Hattori T.
  • Expression of cytokeratins 7 and 20 in serrated adenoma and related diseases.
  • Dig Dis Sci 50 (9) : 1741-1746, 2005  <PubMed Abstract>

⑥ 精巣腫瘍の分子遺伝学

(本学泌尿器科学講座との共同研究)

  • Kawakami T, Zhang C, Taniguchi T, Kim CJ, Okada Y, Sugihara H, Hattori T, Reeve AE, Ogawa O, Okamoto K.
  • Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells.
  • Oncogene 3 (36) : 6163-6169, 2004  <PubMed Abstract>
  • Kawakami T, Okamoto K, Sugihara H, Hattori T, Reeve AE, Ogawa O, Okada Y.
  • The MET proto-oncogene is not a major target for the gain of chromosome 7 in testicular germ-cell tumors of adolescents.
  • Virchows Arch 444 (5) : 480-481, 2004  <PubMed Abstract>
  • Kawakami T, Okamoto K, Kataoka A, Koizumi S, Iwaki H, Sugihara H, Reeve AE, Ogawa O, Okada Y.
  • Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas.
  • Genes Chromosomes Cancer 38 (1) : 97-101, 2003  <PubMed Abstract>
  • Kawakami T, Okamoto K, Sugihara H, Hattori T, Reeve AE, Ogawa O, Okada Y.
  • The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors.
  • J Urol 169 (4) : 1546-52, 2003  <PubMed Abstract>