②-1 胆汁による発癌と癌進展:胃発癌の研究

  • Terasaki M, Totsuka Y, Nishimura K, Mukaisho K, Chen KH, Hattori T, Takamura-Enya T, Sugimura T, Wakabayashi K.
  • Detection of endogenous DNA adducts, O(6)-carboxymethyl-2′-deoxyguanosine and 3-ethanesulfonic acid-2′-deoxycytidine, in the rat stomach after duodenal reflux.
  • Cancer Sci 99 (9) : 1741-1746, 2008  <PubMed Abstract>
  • Suo M, Mukaisho K, Shimomura A, Sugihara H, Hattori T.
  • Thioproline prevents carcinogenesis in the remnant stomach induced by duodenal reflux.
  • Cancer Lett 237 (2) : 256-262, 2006  <PubMed Abstract>
  • Mukaisho K, Miwa K, Kumagai H, Bamba M, Sugihara H, Hattori T.
  • Gastric carcinogenesis by duodenal reflux through gut regenerative cell lineage.
  • Dig Dis Sci 48 (11) : 2153-2158, 2003  <PubMed Abstract>

②-2 胆汁による発癌と癌進展:バレット食道及び食道腺癌、食道扁平上皮癌の研究

  • Mukaisho K, Nakayama T, Hagiwara T, Hattori T, Sugihara H.
  • Two distinct etiologies of gastric cardia adenocarcinoma: interactions among pH, Helicobacter pylori, and bile acids.
  • Front Microbiol. 2015 May 11;6:412. doi: 10.3389/fmicb.2015.00412. eCollection 2015.   <PubMed Abstract>
  • Mukaisho K, Hagiwara T, Nakayama T, Hattori T, Sugihara H.
  • Potential mechanism of corpus-predominant gastritis after PPI therapy in Helicobacter pylori-positive patients with GERD.
  • World J Gastroenterol. 2014 Sep 14;20(34):11962-5. doi: 10.3748/wjg.v20.i34.11962. Review.   <PubMed Abstract>
  • Miyashita T, Tajima H, Munemoto M, Shah FA, Harmon JW, Watanabe T, Shoji M, Okamoto K, Nakanuma S, Sakai S, Kinoshita J, Makino I, Nakamura K, Hayashi H, Oyama K, Inokuchi M, Nakagawara H, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Mukaisho K, Fujimura T, Ohta T.
  • Impact of histone deacetylase 1 and metastasis-associated gene 1 expression in esophageal carcinogenesis.
  • Oncol Lett. 2014 Aug;8(2):758-764. Epub 2014 May 26.   <PubMed Abstract>
  • Macke RA, Nason KS, Mukaisho K, et al.
  • Barrett’s esophagus and animal models.
  • Annals of the New York Academy of Sciences, 1232 : 392-400, 2011   <PubMed Abstract>
  • 向所 賢一, 九嶋 亮治, 竹村 しづき, 荒木 克夫, Michael Vieth, 杉原 洋行, 服部 隆則
  • Barrett食道の組織発生-人体病理と実験病理から
  • 胃と腸, 46: 1861-1874, 2011
  • 向所 賢一, 服部 隆則, 荒木 克夫, 杉原 洋行
  • Barrett食道腺癌の成因と発癌のメカニズムはどこまで解明されているか
  • 消化器の臨床, 14: 449-454, 2011
  • Ling ZQ, Mukaisho K, Yamamoto H, Chen KH, Asano S, Araki Y, Sugihara H, Mao WM, Hattori T.
  • Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma.
  • Cancer Sci 101 (3) : 624-30, 2010  <PubMed Abstract>
  • 向所 賢一, 杉原 洋行, 服部 隆則
  • 病理医から見たBarrett粘膜とBarrett腺癌―米国人に多いLSBEと我が国に多いSSBEの組織型の違いについて
  • G.I. Research 18 (1) : 13-18, 2010  <PDF>
  • Chen KH, Mukaisho K, Sugihara H, Araki Y, Yamamoto G, Hattori T.
  • High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett’s esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model.
  • Cancer Sci 98 (11) : 1683-8, 2007  <PubMed Abstract>
  • Chen KH, Mukaisho K, Ling ZQ, Shimomura A, Sugihara H, Hattori T.
  • Association between duodenal contents reflux and squamous cell carcinoma–establishment of an esophageal cancer cell line derived from the metastatic tumor in a rat reflux model.
  • Anticancer Res 27 (1A) : 175-8, 2007  <PubMed Abstract>
  • Tatsuta T, Mukaisho K, Sugihara H, Miwa K, Tani T, Hattori T.
  • Expression of Cdx2 in early GRCL of Barrett’s esophagus induced in rats by duodenal reflux.
  • Dig Dis Sci 50 (3) : 425-431, 2005  <PubMed Abstract>
  • Kumagai H, Mukaisho K, Sugihara H, Miwa K, Yamamoto G, Hattori T.
  • Thioproline inhibits development of esophageal adenocarcinoma induced by gastroduodenal reflux in rats.
  • Carcinogenesis 25 (5) : 723-727, 2004  <PubMed Abstract>
  • Kumagai H, Mukaisho K, Sugihara H, Miyashita T, Miwa K, Hattori T.
  • Cell kinetic study on histogenesis of Barrett’s esophagus using rat reflux model.
  • Scand J Gastroenterol 38 (7) : 687-692, 2003  <PubMed Abstract>

②-3 胆汁による発癌と癌進展:胃食道逆流症(GERD)食道外病変の研究

  • Oue K, Mukaisho K, Higo T, Araki Y, Nishikawa M, Hattori T, Yamamoto G, Sugihara H.
  • Histological examination of the relationship between respiratory disorders and repetitive microaspiration using a rat gastro-duodenal contents reflux model.
  • Exp Anim 60 (2) : 141-50, 2011  <PubMed Abstract>
  • Higo T, Mukaisho K, Ling ZQ, Oue K, Chen KH, Araki Y, Sugihara H, Yamamoto G, Hattori T.
  • An animal model of intrinsic dental erosion caused by gastro-oesophageal reflux disease.
  • Oral Dis 15 (5) : 360-5, 2009  <PubMed Abstract>
  • Mukaisho K, Araki Y, Sugihara H, Tanaka H, Chen KH, Hattori T.
  • High serum bile acids cause hyperthyroidism and goiter.
  • Dig Dis Sci 53 (5) : 1411-6, 2008  <PubMed Abstract>
  • Ling ZQ, Mukaisho K, Hidaka M, Chen KH, Yamamoto G, Hattori T.
  • Duodenal contents reflux-induced laryngitis in rats: possible mechanism of enhancement of the causative factors in laryngeal carcinogenesis.
  • Ann Otol Rhinol Laryngol 116 (6) : 471-8, 2007  <PubMed Abstract>

 

 

②-5 胆汁による発癌と癌進展:胆汁酸の癌進展への影響

  • Sato S, Yamamoto H, Mukaisho K, Saito S, Hattori T, Yamamoto G, Sugihara H.
  • Continuous taurocholic acid exposure promotes esophageal squamous cell carcinoma progression due to reduced cell loss resulting from enhanced vascular development.
  • PLoS One. 2014 Feb 14;9(2):e88831. doi: 10.1371/journal.pone.0088831. eCollection 2014. <PLOS ONE><PubMed Abstract>
  • Saito S, Yamamoto H, Mukaisho K, Sato S, Higo T, Hattori T, Yamamoto G, Sugihara H.
  • Mechanisms Underlying Cancer Progression Caused by Ezrin Overexpression in Tongue Squamous Cell Carcinoma.
  • PLoS One. 2013;8(1):e54881. doi: 10.1371/journal.pone.0054881. Epub 2013 Jan 24.  <PLOS ONE><PubMed Abstract>