2004年までの主な成果

1984 服部 隆則:消化管 I 発生、正常組織、細胞動態. 現代病理学大系12A、9-40、中山書店.

1985 Hattori T: Morphological range of hyperplastic poloypsand carcinomas arising in hyperplastic polyps of the stomach. J ClinPathol 38 (6): 622-630.

1986 Hattori T: Development of adenocarcinomas in the stomach. Cancer 57 (8): 1528-1534.

1987 Sugihara H: Hattori T, Fukuda M, Fujita S: Cell proliferation and differentiation in intramucosal and advanced signet ringcell carcinomas of the human stomach. Virchows Arch 411(2): 117-127.

1993a Kushima R, Hattori T: Histogenesis and characteristics of gastric-type adenocarcinoma in the stomach. J Cancer ResClin Oncol 120: 103-111

1993b Kushima R, Jancic S, Hattori T: Association between expression of sialosyl-Tn antigen and intestinalization of gastriccarcinomas. Int J Cancer 55: 904-908.

1993 Sugihara H, Hattori T, Fukuda M, Katsura K, Fujita S: Progression of signet ring cell carcinomas in the humanstomach. Cancer 71(6): 1938-47

1994 服部隆則、杉原洋行: 消化管上皮の細胞回転からみた癌の発生. 病理と臨床12 (5): 583-589.

1994 Miwa K, Segawa M, Takano Y, Matsumoto H, Sahara H, Yagi M, Miyazaki I, Hattori T: Induction of oesophagealand forestomach carcinomas in rats by reflux of duodenal contents. Br J Cancer 70: 185-189

1994 Kushima R, Moritani S, Hattori T: Over-expression of p53 protein in gastric carcinomas: relationship withdevelopment, progression adn muin-histochemical differentiation. The Cancer J 7(2): 192-197

1995 服部隆則、九嶋亮治、内藤弘之、野田昌夫: 胃型腺癌の組織発生と遺伝子異常. 病理と臨床 13 (1): 45-51.

1995 Ohmura M, Hattori T, A possible multiclonal development in human colonic carcinomas. J Cancer Res Clin Oncol 121(6): 321-326

1995 Naitoh H, Shibata J, Kawaguchi A, Kodama M, Hattori T: Overexpression and localization of cyclin D1 mRNA andantigen in esophageal cancer. Am J Pathol 146(5): 1161-1169

1995 Konishi H: Tumorigensis of gastric endocrine cell tumor. J Kyoto Pref Univ Med 104(3): 465-483

1996 Moritani S, Kushima R, Sugihara H, Hattori T: Phenotypic characteristics of Epstein-Barr-virus-associated gastriccarcinomas. J Cancer Res Clin Oncol 122: 750-756

1996 中野克哉: Barrett食道の発生と特性に関する臨床病理学的および実験的検討。京府医大誌 105(5): 679-691

1996 杉原洋行、服部隆則: 未分化型胃癌の進展様式からみた表層拡大型早期胃癌. 胃と腸 31 (5): 613-621.

1996 Miwa K, Sahara H, Sagawa M, Kinami S, Sato T, Miyazaki I, Hattori T: Reflux of duodenal or gastro-duodenalcontents induces esophageal carcinoma in rats. Int J Cancer 67(2): 269-274

1997 Nakajima S, Krishan B, Ota H, Sehura AM, Hattori T, Graham DY, Genta RM: Mast cell involvement in gastritis withor without Hericobacter pylori infection. Gastroenterology 113: 746-754

1997 Kushima R, Borchard F, Hattori T: A new aspect of gastric metaplasia in Crohn’s disease: bidirectional (foveolar andpyloric) differentiation in so-called “pyloric metaplasia” in the ileum. Pathol Int 47: 416-419

1997 Tsujimoto H, Sugihara H, Hagiwara A, Hattori T: Amplification of growth factor receptor genes and DNA ploidypattern in the progression of gastric cancer. Virchows Arch 431: 383-389

1998 服部隆則: 胃腺腫の病理-腸型、胃型腺腫とdysplasia. 病理と臨床 16 (1): 10-16.

1998 九嶋亮治、服部隆則: 増殖動態と分化マーカーからみた胃腺腫と腺癌の鑑別. 病理と臨床 16 (1): 17-23

1998 Efstathiou JA, Noda M, Rowan A, Dixon C, Chinery R, Jawhari A, Hattori T, Wright NA , Bodmer WF,Pignatelli M: Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells. Proc Natl Acad Sci USA 95: 3122-3127

1998 Bamba M, Sugihara H, Okada K, Bamba T, Hattori T: Clonal analysis of superficial depressed-type gastric carcinomain humans. Cancer 83(5): 867-875

1998 Wu L-B, Kushima R, Borchard F, Molsberger G, Hattori T: Intramucosal carcinomas of the stomach: phenotypicexpression and loss of heterozygocity at microsatellites linked to the APC gene. Pathol Res Pract 194: 405-412

1998 Kimura T, Sugihara H, Mitsufuji S, Kodama T, Hattori T: Microsatellite analysis and DNA ploidy pattern in signet-ringcell carcinoma and well differentiated adenocarcinoma of the stomach. The Cancer J 11(6): 298-305

1998 Yao X-H, Sugihara H, Hattori T, Katsura K, Takamatsu T: Regulation of apoptotic cell death in the pyloric glands ofthe canine stomach. Virchows Arch 433: 275-280

1999a Kushima R, Manabe R, Hattori T, Borchard F: Histogenesis of gastric foveolar metaplasia following duodenal ulcer:a definite reparative lineage of Brunner’s gland. Histopathology 35: 38-43

1999b Kushima R, Ruthlein HJ, Stolte M, Bamba M, Hattori T, Borchard F: “Pyloric gland-type adenoma” arising inheterotopic gastric mucosa of the duodenum. Virchows Arch 435: 452-457

1999 宮下知治、三輪晃一、藤村隆、服部隆則: ラットの十二指腸液逆流によるBarrett食道の組織発生. 医学のあゆみ 191(3): 245-246

1999 服部隆則、九嶋亮治、杉原洋行、馬場正道: 胃型ならびに腸型腺癌の遺伝子変化. 胃と腸 34 (4): 527-537.

2000 Ohene-Abuakwa Y, Noda M, Perenyi M, Kobayashi N, Kashima K, Hattori T, Pignatelli M: Expression of the E-cadherin/catenin (α-, β-, and γ-) complex correlates with the microscopic appearance of early gastric cancer. J Pathol 192: 433-439

2000 Okada K, Sugihara H, Bamba M, Bamba T, Hattori T: Sequential numerical changes of chromosomes 7 and 18 indiffuse-type stomach cancer cell lines: combined comparative genomic hybridization, fluorescence in situ hybridization and ploidyanalyses. Cancer Genet Cytogenet 118: 99-107

2000 Zhan G-Z, Sugihara H, Peng D-F, Ling Z-Q , Yao X-H, Yoshitake K, Hattori T: Role of p53 in growthsuppression by bromodeoxyuridine in human gastric cancer cell lines. Acta Histochem Cytochem 33(6): 429-437

2000 九嶋亮治: 粘膜修復と粘液形質 – 消化管粘膜共通の原理. 細胞 32(8): 303-307

2001 Peng D-F, Sugihara H, Hattori T, Bromodeoxyuridine induces p53-dependent and -independent cell cycle arrests inhuman gastric carcinoma cell lines. Pathobiology 69: 77-85

2001 Bamba M, Sugihara H, Kushima R, Okada K, Tsukashita S, Hattori T: Time dependent expression of intestinalphenotype in signet ring cell carcinoma of the human stomach. Virchows Arch 438: 49-56

2001 Tsukashita S, Kushima R, Bamba M, Sugihara H, Hattori T: MUC gene expression and histogenesis ofadenocarcinoma of the stomach. Int J Cancer 94: 166-170

2001a Hattori T, Kushima R: Das gastral differenzierte Magenadenokarzinom. Der Pathologe 22: 97-104

2001 杉原洋行: CGHの定量的解析:interphase karyotypingへの試み. Cytometry Res 11(1): 1-7

2001 Kirchner T, Muller S, Hattori T, Mukaisho K, Papadopoulos T, Brabletz T, Jung A: Metaplasia, intraepithelialneoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by cytokeratin-7 expression ingastritis. Virchows Arch 439(4): 512-522

2001 Tamura H, Sugihara H, Bamba M, Tani T, Hosokawa M, Kodama M, Hattori T: Clonal analysis of esophagealsquamous cell carcinoma with intraepithelial components. Pathobiology 69: 289-296

2001 Ruiz B, Garay J, Johnson W, Li D, Rugge M, Dixon MF, Fiocca R, Genta RB, Hattori T, Lechago J, Price AB,Sipponen P, Solcia E, Watanabe H, Correa P: Morphometric assessment of gastric antral atrophy: comparison with visualevaluation. Histopathology 39(3): 235-242

2001b 服部隆則、九嶋亮治: Helicobacter pyloriと胃癌 b. 病理学的考察. 病理と臨床 19 (8): 837-841.

2002 Kamitani S, Sugihara H, Shiomi H, Tani T, Hattori T: Intratumoral regional variations in copy number of thechromosomal part revealed by microdissection and combined ploidy and comparative genomic hybridization analyses in esophagealsquamous cell carcinoma. Cancer Genet Cytogenet 132: 30-35

2002 Bamba N, Nakajima S, Andoh A, Bamba M, Sugihara H, Hattori T: Stem cell factor expressed in human gastricmucosa in relation to mast cell increase in Helicobacter pylori-infected gastritis. Dig Dis Sci 47(2): 274-282

2002a Moritani S, Sugihara H, Kushima R, Hattori T: Different roles of p53 between Epstein Barr Virus-positive and -negative gastric carcinomas of matched histology. Virchows Arch 440: 367-375

2002 Tokugawa T, Sugihara H, Tani T, Hattori T: Modes of silencing of p16 in development of esophageal squamous cellcarcinoma. Cancer Res 62: 4938-4944

2002a Mukaisho K, Sugihara H, Tani T, Kurumi Y, Kamiatni S, Tokugawa T, Hattori T: Effects of microwave irradiationon rat hepatic tissue evaluated by enzyme histochemistry for acid phosphatase. Dig Dis Sci 47(2): 376-379

2002b Moritani S, Ioffe OB, Sagae S, Dahmoush L, Silverberg SG, Hattori T: Mitotic activity and apoptosis inendocervical glandular lesions. Int J Gynecol Pathol 21(2): 125-133

2002c Moritani S, Kushima R, Sugihara H, Bamba M, Kobayashi T, Hattori T: Availability of CD10immunohistochemistry as a marker of breast myoepithelial cells on paraffin sections. Modern Pathology 15(4): 397-405

2002 Kushima R, Stolte M, Dirks K, Vieth M, Okabe H, Borchard F, Hattori T: Gastric-type adenocarcinoma of theduodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner’s glands.Virchows Arch 440: 655-659

2002 Rugge M, Correa P, Dixon MF, Fiocca R, Hattori T, Lechago J, Leandro G, Price AB, Sipponen P, Solcia E,Watanabe H, Genta RM: Gastric mucosal atrophy : interobserver consistency using new criteria for classification and grading.Aliment Pharmacol Ther 16(7): 1249-59

2002b Mukaisho K, Suo M, Shimakage M, Kushima R, Inoue H, Hattori T: Down-regulation of drs mRNA in ColorectalNeoplasms. Jpn J Cancer Res 93: 888-893

2002c Mukaisho K, Kurumi Y, Sugihara H, Naka S, Kamitani S, Tsubosa Y, Moritani S, Endo Y, Hanazawa K,Morikawa S, Inobushi T, Hattori T, Tani T: Enzyme histochemistry is useful to assess viability of tumor tissue after microwavecoagulation therapy(MCT) – Metastatic adenocarcinoma treated by lateral segmentectomy after MCT. Dig Dis Sci 47(11): 2441-2445

2002 Noda M, Tatsumi Y, Tomizawa M, Takama T, Mitsufuji S, Sugihara H, Kashima K, Hattori T: Effects of etodolac,a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines. Journal ofGastroenterology 37: 896-904

2002 Tsujimoto H, Hagiwara A, Sugihara H, Hattori T, Yamagishi H: Promoter methylations of p16INK4a and p14ARFgenes in early and advanced gastric cancer. Correlations of the modes of their occurrence with histologic type. Pathol Res Pract198: 785-794.

2003 Tsukashita S, Kushima R, Bamba M, Nakamura E, Mukaisho K, Sugihara H, Hattori T: Beta-catenin expressionin intramucosal neoplastic lesions of the stomach: comparative analysis of adenoma/dysplasia, adenocarcinoma and signet ring cellcarcinoma. Oncology 64(3):251-258

2003 Kumagai H, Mukaisho K, Sugihara H, Bamba M, Miyashita T, Miwa K, Hattori T.:Cell kinetic study onhistogenesis of Barrett’s esophagus using rat reflux model. Scand J Gastroenterol. 38(7):687-692

2003 Moritani S, Kushima R, Bamba M, Kobayashi T, Oka H, Fujimoto M, Hattori T, Okabe H: Highly anaplasticextraventricular ependymoma arising in an adult, mimicking metastatic adenocarcinoma with heavy stromal inflammation andemperiporesis. Pathology International 53:539-546

2003 Tomoda C, Kushima R, Takeuchi E, Mukaisho K, Hattori T, Kitano H: CD10 expression is useful in the diagnosisof folicular carcinoma and follicular variant of papillary thyroid carcinoma. Thyroid 13(3):291-295

2003 Shiomi H, Sugihara H, Kamitani S, Tokugawa T, Tsubosa Y, Okada K, Tamura H, Tani T, Kodama M, HattoriT: Cytogenetic heterogeneity and progression of esophageal squamous cell carcinoma. Cancer Genetics and Cytogenetics 147:50-61

2003a 九嶋亮治、向所賢一、塚下しづき、彭敦発、杉原洋行、Michael Vieth、Manfred Stolte、服部隆則:胃型分化型早期胃癌の分子生物学的特徴。胃と腸 38(5):707-721

2003b 九嶋亮治、向所賢一、馬場正道、岡部英俊、Michael Vieth、Franz Borchard、Manfred Stolte、服部隆則:胃腺腫の病理診断 -特に胃型(幽門腺型)腺腫について-。 胃と腸 38(10):1377-1387

2003 Peng D-F, Sugihara H, Mukaisho K, Tsubosa Y, Hattori T: Alterations of chromosomal copy number duringprogression of diffuse-type gastric carcinomas: metaphase- and array-based comparative genomic hybridization analyses ofmultiple samples from individual tumours. J Pathol 201: 439-450

2003 Mukaisho K, Miwa K, Kumagai H, Bamba M, Sugihara H, Hattori T: Gastric carcinogenesis by duodenal refluxthrough gut regenerative cell lineage. Dig Dis Sci 48(11): 2153-8

2004 Kumagai H, Mukaisho K, Sugihara H, Miwa K, Yamamoto G, Hattori T: Thioproline inhibits development ofesophageal adenocarcinoma induced by gastroduodenal refluxin rats. Carcinogenesis 25(5):723-727