③ デキストラン硫酸ナトリウムによるラット実験大腸炎

(荒木克夫客員准教授との共同研究)

  • Araki Y, Bamba T, Mukaisho K, Kanauchi O, Ban H, Bamba S, Andoh A, Fujiyama Y, Hattori T, Sugihara H.
  • Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis.
  • Oncology Reports, 28 (5) : 1597-1605, 2012 <PubMed Abstract>
  • Araki Y, Mukaisho K, Sugihara H, Fujiyama Y, Hattori T.
  • Proteus mirabilis sp. intestinal microflora grow in a dextran sulfate sodium-rich environment.
  • Int J Mol Med 25 (2) : 203-208, 2010  <PubMed Abstract>
  • Araki Y, Mukaisyo K, Sugihara H, Fujiyama Y, Hattori T.
  • Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice.
  • Oncol Rep 24 (4) : 869-874, 2010  <PubMed Abstract>
  • Araki Y, Mukaisho K, Sugihara H, Fujiyama Y, Hattori T.
  • Detection of N-nitroso-bile acids at 285 nm in reverse-phase HPLC.
  • J Sep Sci 31 (15) : 2827-2830, 2008  <PubMed Abstract>
  • Araki Y, Mukaisho K, Sugiahra H, Hattori T.
  • Decomposition of dextran sulfate sodium under alkaline, acidic, high temperature and high pressure conditions.
  • Oncol Rep 20 (1) : 147-149, 2008  <PubMed Abstract>
  • Araki Y, Sugihara H, Hattori T.
  • Chemical depolymerization of dextran sulfate sodium – the application of size-exclusion or ion-pair liquid chromatography.
  • Biomed Chromatogr 21 (4) : 335-337, 2007  <PubMed Abstract>
  • Araki Y, Kanauchi O, Sugihara H, Fujiyama Y, Hattori T.
  • Germinated barley foodstuff suppresses dextran sulfate experimental colitis in rats: the role of mast cells.
  • Int J Mol Med 19 (2) : 257-262, 2007  <PubMed Abstract>
  • Araki Y, Sugihara H, Hattori T.
  • In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis.
  • Oncol Rep 16 (6) : 1357-1362, 2006  <PubMed Abstract>
  • Araki Y, Sugihara H, Hattori T.
  • The free radical scavengers edaravone and tempol suppress experimental dextran sulfate sodium-induced colitis in mice.
  • Int J Mol Med 17 (2) : 331-4, 2006  <PubMed Abstract>